Endocrine Abstracts

In patients with longstanding type 1 diabetes β-cell regeneration or β-cell replacement are the only options that result in normoglycemia without the risk of hypoglycemia. Although persistent C-peptide is present in ~10% of patients with type 1 diabetes, currently regeneration of eutopic pancreatic islets remains elusive due to the minimal regenerative capacity of the human pancreas and the presence of persistent autoreactivity. Islet transplantation is a form of &#9...

The efficacy of human islet transplantation is reduced by loss of islets directly after transplantation. Ischemia is likely to be an important contributing factor to the observed islet loss. Diazoxide inhibits insulin secretion by beta cells and has been shown to exhibit anti-apoptotic and anti-ischemic effects. We hypothesized that preincubation of human islets with diazoxide leads to improved islet survival and graft function.Methods: Isolated human pa...

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Introduction: Pancreatic β-cells control glucose homeostasis by secreting insulin in response to high glucose. MiRNAs regulate β-cell function and contribute to β-cell failure in type 2 diabetes. MiR-184 regulates β-cell compensatory expansion during pregnancy and obesity and its expression is reduced by glucose through unknown mechanisms. AMPK is a suggested target of antidiabetic drugs and an important energy sensor. Its β-cell-selective inactivation...